• The signs and symptoms of syphilis are related to the stage of the infection.

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• The first stage involves the appearance of a painless sore on the genitals, rectum, or mouth.

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• After the sore heals, the second stage will usually manifest with a rash.

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• Finally, after a long period with no symptoms, the third stage can suddenly develop, causing extensive damage to the brain, nerves, eyes, or heart.